The River and Rail

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The River and Rail, a southern Bistro, is located in the landmark Lipes Pharmacy, a South Roanoke institution. Chef Tyler Thomas changes the menu regularly based on the availability of seasonal products from local, high-end providers. He and his team produce updated Southern and French classic dishes for this neighborhood bistro. Have a signature cocktail at the bar or enjoy wine and beer from our thoughtfully curated lists. River and Rail Restaurant has been voted "Best Restaurant in Roanoke" countless times, recognized as one of the Top 10 Best Fine Dining Restaurants in the South by USA Today, featured in Garden & Gun magazine, and selected twice as on of the Top 100 Restaurants in the South by Southern Living Magazine.

  • Map View:
  • Directions: From I-581/US 220, take exit to Wonju Street toward Franklin Road. Continue down the hill and Wonju and go straight through the intersection and this road will become Broadway Avenue. Go 1/4 mile on Broadway and turn right on 22nd Street. Take 22nd Street for 1/4 mile and turn right on Crystal Spring Avenue - the restaurant will be on the right.
  • Major Access Routes: I-581, US 220
  • Monday Hours: Closed
  • Tuesday Hours: 5pm - 8:30pm
  • Wednesday Hours: 5pm - 8:30pm
  • Thursday Hours: 5pm - 8:30pm
  • Friday Hours: 5pm - 8:30pm
  • Saturday Hours: 5pm - 8:30pm
  • Sunday Hours: Closed
  • Dinner Served:
  • Alcohol Served:
    • Beer
    • Cocktails
    • Wine
  • Bar/Lounge:
  • Vegetarian Options:
  • Entree Price Range: $20 - $29
  • Credit Cards Accepted:
  • Outdoor Dining:
  • Reservations: Recommended
  • Smoke Free:
  • Additional Information: Brunch served on Sundays.