The River and Rail, a southern Bistro, is located in the landmark Lipes Pharmacy, a South Roanoke institution. Chef Tyler Thomas changes the menu regularly based on the availability of seasonal products from local, high-end providers. He and his team produce updated Southern and French classic dishes for this neighborhood bistro. Have a signature cocktail at the bar or enjoy wine and beer from our thoughtfully curated lists. River and Rail Restaurant has been voted "Best Restaurant in Roanoke" countless times, recognized as one of the Top 10 Best Fine Dining Restaurants in the South by USA Today, featured in Garden & Gun magazine, and selected twice as on of the Top 100 Restaurants in the South by Southern Living Magazine.